Regulation of adrenoceptors and muscarinic receptors in the heart.

نویسندگان

  • J Myslivecek
  • S Trojan
چکیده

Receptor activation results in homologous regulation and can also affect other types of receptors (a process that has been reported to heterologous regulation). Heart cells express subtypes of muscarinic receptors and adrenoceptors, almost antagonistic in their action (M2 muscarinic receptors and beta1-adrenoceptors). Therefore, they provide an excellent model of heterologous regulation. Moreover, the minor subtypes of adrenoceptors and muscarinic receptors have been identified in the heart cells. The physiological significance of the minor subtypes is now under keen investigation and their function can be considered as complementary to the major subtypes. Taken together, it seems that the minor subtypes may play an important role in the receptor-heart function homeostasis and that heterologous regulation seems to exist in many heart receptor types and in the above mentioned pair of receptors.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Crossing interaction of adrenergic, cholinergic, histaminergic and opioidergic systems on water intake in adult male rats

Several lines of evidence have indicated that many nuclei in the brain including preoptic nucleus, AV3V, subfornical organ, septal area and lateral hypothalamus are the targets of efferents from chemo-sensitive and pressure-sensitive systems. These areas may concern with regulation of fluid homeostasis. In the present study, intracerebroventricular injections were carried out in all experiments...

متن کامل

Crossing interaction of adrenergic, cholinergic, histaminergic and opioidergic systems on water intake in adult male rats

Several lines of evidence have indicated that many nuclei in the brain including preoptic nucleus, AV3V, subfornical organ, septal area and lateral hypothalamus are the targets of efferents from chemo-sensitive and pressure-sensitive systems. These areas may concern with regulation of fluid homeostasis. In the present study, intracerebroventricular injections were carried out in all experiments...

متن کامل

The role of muscarnic cholinergic receptor of the bed nucleus of stria terminalis on cardiovascular response and baroreflex modulation in rat.

Introduction: The bed nucleus of the stria terminalis (BST) is a limbic structure which is involved in cardiovascular regulation and baroreflex modulation. The presence of cholinergic synaptic terminalis with high level of muscarinic receptors in the BST has been demonstrated. This study was performed to find the role of the cholinergic muscarinic receptor in cardiovascular response and baro...

متن کامل

The Effect of Chronic Inflammation on Knee Joint Vascular β-adrenoceptors in Rabbit

It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular- ß adrenoceptors are changed due to acute inflammation from a majority of ß-1 to an equality of ß-1 and ß-2 receptors.. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular ß-adrenoceptors ...

متن کامل

The role of acetylcholine muscarinic receptors in the rat basolateral amygdala on morphine-induced place preference

Some studies have shown that acetylcholine muscarinic receptors involved in the opiate reward. In the present study, the effect of intra-basolateral amygdale (BLA) acetylcholine muscarinic like receptor agonist (physostigmine) and antagonist (atropine) on the acquisition of morphine-induced place preference has been investigated in male Wistar rats. For this purpose, two 22 gauges guide cannula...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • General physiology and biophysics

دوره 22 1  شماره 

صفحات  -

تاریخ انتشار 2003